The San Francisco 49ers' running back situation remains a hot topic for fantasy football enthusiasts as Isaac Guerendo is expected to play against the Los Angeles Rams despite being listed as questionable due to a sprained foot.

Guerendo's recent performance, including 78 rushing yards and two touchdowns against the Chicago Bears, highlights the potential of any 49ers running back in Kyle Shanahan's system. With Christian McCaffrey and Jordan Mason sidelined, fantasy players are closely monitoring Guerendo and Patrick Taylor Jr. for their late-season lineups.