The San Francisco 49ers are facing significant injury challenges, particularly in their backfield, with multiple key players sidelined. As a result, rookie Isaac Guerendo has stepped up as the starting running back despite dealing with his own injury.

Guerendo's performance in Week 14 was impressive, leading to speculation about his readiness for the critical matchup against the Los Angeles Rams in Week 15. Although he missed practice early in the week, he has shown determination to play, making him a viable option for fantasy players.