San Francisco 49ers running back Christian McCaffrey sustained a knee injury during the team's 35-10 defeat against the Buffalo Bills, raising concerns about a potentially season-ending issue. Coach Kyle Shanahan indicated that McCaffrey may have injured his posterior cruciate ligament (PCL), but no recovery timeline has been established.

This injury adds to a challenging season for McCaffrey, who had already missed the first eight games due to Achilles tendinitis. He had shown some promise in the game with a 19-yard run before the injury occurred.