San Francisco 49ers running back Christian McCaffrey will miss the remainder of the regular season due to a knee injury, though he won't require surgery. Coach Kyle Shanahan expressed his disappointment for McCaffrey, who has faced a challenging season, including an earlier Achilles injury.

With McCaffrey sidelined, the 49ers will rely on rookie Isaac Guerendo and promote Patrick Taylor. The team is also looking to add another running back as they struggle in the NFC West standings.