The San Francisco 49ers are gearing up for a crucial Week 2 game against the Minnesota Vikings, who have revamped their lineup with new players like quarterback Sam Darnold and running back Aaron Jones. The 49ers are looking to break a seven-game road losing streak in Minnesota, a challenge highlighted by defensive end Nick Bosa.

Key players to watch for the 49ers include tight end George Kittle, who is nearing a significant milestone in his career, and safety Ji’Ayir Brown, who is expected to capitalize on opportunities against Darnold. Quarterback Brock Purdy faces a tricky defense, while tackle Colton McKivitz aims to improve his performance after a solid first game. Defensive tackle Maliek Collins will be vital in stifling the Vikings' running game.