The San Francisco 49ers face the New York Jets in their season opener, but injuries could significantly affect their lineup. Safety Talanoa Hufanga is doubtful due to a knee injury, while running back Christian McCaffrey and left guard Aaron Banks are both questionable.

Defensive end Yetur Gross-Matos and linebacker Dee Winters have been ruled out. The 49ers may elevate practice squad players to fill gaps in their lineup, particularly with injuries impacting their defense.