The San Francisco 49ers faced a tough loss against the Kansas City Chiefs, primarily due to injuries that have depleted their roster. Star receiver Brandon Aiyuk suffered a torn ACL and MCL, sidelining him for the season, while Deebo Samuel was hospitalized with pneumonia. Brock Purdy struggled with limited options, throwing three interceptions and posting a career-low passer rating.

Despite the challenges, coach Kyle Shanahan remains hopeful, emphasizing the potential of rookies and remaining players to step up. The 49ers' pass defense performed well, limiting Patrick Mahomes significantly, but their special teams faced issues with punt coverage. With a critical matchup against the Dallas Cowboys upcoming, the team is looking for reinforcements before the trade deadline.