The San Francisco 49ers face challenges ahead of their matchup against the Green Bay Packers, with offensive lineman Jon Feliciano officially ruled out due to a knee injury. Feliciano, who recently signed a one-year extension, has yet to play this season after starting on injured reserve.

In a positive turn, the 49ers have promoted veteran safety Tashaun Gipson Sr. to the active roster. Additionally, linebacker Jalen Graham and cornerback Nick McCloud have been activated from the practice squad. Key players like Trent Williams and Brock Purdy remain questionable or out for the game.