The San Francisco 49ers and Tampa Bay Buccaneers face significant injury challenges ahead of their crucial matchup. While the 49ers are hoping for the return of Christian McCaffrey, the Buccaneers are struggling with key players like Mike Evans and Chris Godwin sidelined.

Despite their recent struggles, Baker Mayfield's performance has been a bright spot for Tampa Bay. Both teams are vying for playoff positions, making this game critical for their postseason hopes. Betting insights suggest a potential high-scoring affair, especially with McCaffrey's return.