Jacksonville Jaguars tight end Evan Engram is dealing with a hamstring strain and is not expected to play against the Buffalo Bills. Coaches suggest considering Brenton Strange as a streaming option.

The Bills will be missing several key defensive players, including linebackers Matt Milano and Terrel Bernard, which may aid the Jaguars' passing game.

San Francisco 49ers tight end George Kittle is also suffering from hamstring issues, making his availability uncertain for the upcoming game against the Los Angeles Rams.

Tennessee Titans tight end Chig Okonkwo faces a struggling Green Bay Packers coverage unit this week, while Packers wide receiver Jayden Reed is expected to play but has been managing calf injuries.

Meanwhile, the Los Angeles Rams continue to cope without Cooper Kupp, reworking their receiving corps, and Kansas City Chiefs’ Isiah Pacheco has been placed on injured reserve following surgery for a fractured fibula.