Michael Penix Jr. led the Atlanta Falcons to a decisive 34-7 victory over the New York Giants, who suffered their 10th consecutive loss. The Falcons' defense shined with two pick-sixes, while Penix completed 18 of 27 passes for 202 yards in his first start.
In other games, Matthew Stafford's touchdown pass propelled the Los Angeles Rams to a 19-9 win against the New York Jets, and Joe Burrow's three touchdowns helped the Cincinnati Bengals defeat the Cleveland Browns 24-6.
The Detroit Lions continued their impressive season with a 34-17 win over the Chicago Bears, while Washington's Jayden Daniels threw five touchdown passes to upset the Philadelphia Eagles 36-33.
Jonathan Taylor's explosive performance led the Indianapolis Colts to a 38-30 victory over the Tennessee Titans, and Chuba Hubbard's overtime touchdown secured a 36-30 win for the Carolina Panthers against the Arizona Cardinals.
Sam Darnold's late-game heroics helped the Minnesota Vikings edge the Seattle Seahawks 27-24, while the Miami Dolphins defeated the San Francisco 49ers 29-17. The Buffalo Bills overcame the New England Patriots 24-21, and the Las Vegas Raiders snapped a 10-game losing streak with a 19-14 win over the Jacksonville Jaguars.