In Week 16, fantasy football players are advised to consider specific wide receiver and cornerback matchups. DeVonta Smith of the Philadelphia Eagles is highlighted as a player to start confidently against Noah Igbinoghene of the Washington Commanders, especially with the Eagles' injury concerns in their receiving corps.

Meanwhile, Tyler Lockett of the Seattle Seahawks is noted as a player who may no longer be a must-start option, facing Shaquill Griffin of the Minnesota Vikings. Understanding these matchups is crucial for optimizing fantasy lineups.