Curtis Samuel did not return to the game after suffering a shoulder injury, adding to the Bills' injury woes as they were already missing key defensive players.

Curtis Samuel's contributions to the Bills' offense have been minimal, with only 21 rushing yards in a recent game, highlighting concerns about the team's traditional rushing attack. His role is critical as the Bills rely heavily on Josh Allen for offensive output, underscoring the need for a balanced attack to support Allen moving forward.

Curtis Samuel was listed as a limited participant in practice due to a foot injury, indicating he has been managing his condition while preparing for the upcoming game against the Rams.

Curtis Samuel will be one of the available pass-catchers for the Bills in their game against the 49ers, stepping up in the absence of Keon Coleman and Dalton Kincaid. Samuel's presence adds depth to the receiving corps, which will be crucial given the challenging weather conditions expected during the game.

Curtis Samuel struggled to find his footing early in the season, recording only 12 catches in the first nine weeks, largely due to injuries. However, he has recently shown signs of returning to form, logging significant playing time and contributing to the team's success. Over the past two weeks, he has made key plays, including his first touchdown with the Bills, and has begun to display the playmaking ability that characterized his most productive season in 2020. Head coach Sean McDermott has noted Samuel's growing confidence and toughness, which are crucial for the team's offensive strategy.