The 2024-25 NFL Divisional Round brings tough matchups for fantasy football players, with several top-tier defenses making standout performers risky options. Among those likely to disappoint is Houston Texans' Joe Mixon, who faces a formidable Kansas City Chiefs defense allowing the third-fewest rushing yards per game.

Similarly, Washington Commanders' Brian Robinson Jr. will clash with a resurgent Detroit Lions defense, which has shown strength against the run. Buffalo Bills' James Cook also faces a daunting task against the Baltimore Ravens, who have kept running backs in check throughout the season.