The Buffalo Bills secured a solid victory against the Tennessee Titans, winning 34-10 despite a challenging first half. Quarterback Josh Allen excelled, throwing for 323 yards and two touchdowns, while the Bills' defense pressured Titans quarterback Mason Rudolph throughout the game.

Wide receiver Amari Cooper made a notable debut, catching a touchdown, while rookie Keon Coleman led in receiving yards. Defensive ends Greg Rousseau and A.J. Epenesa also shined, consistently disrupting Tennessee's offense. However, punter Sam Martin struggled, averaging only 39.4 yards per punt. Kicker Tyler Bass performed well, contributing significantly to the score.