The Buffalo Bills secured their fifth consecutive AFC East title with a dominant 35-10 win over the San Francisco 49ers, marking a historic early clinch for the division. The Bills showcased a powerful ground game, amassing 222 rushing yards, led by running back James Cook's impressive 107 yards and a notable 65-yard touchdown run.

Quarterback Josh Allen also shone, completing 13 of 17 passes for 148 yards and two touchdowns, including a unique self-throw touchdown. The 49ers struggled offensively, committing three turnovers and losing star running back Christian McCaffrey to a knee injury. Buffalo's defense was relentless, forcing turnovers and stifling San Francisco's offense, further solidifying their postseason aspirations.