Denver's offense began explosively with a 43-yard touchdown pass from Bo Nix to Troy Franklin, setting an early tone in the game. However, the Buffalo Bills' defense quickly shifted the momentum. After that initial score, Nix struggled significantly, managing only 82 passing yards for the remainder of the contest. The Broncos' running game faltered as well, totaling just 25 yards, and they faced challenges converting third downs, going only 1-for-8 in that department.

Buffalo's cornerback Taron Johnson emphasized the importance of a quick recovery after the early touchdown, stating, "When plays like that happen, you’ve got to have a short memory. We did a good job with that today. They didn’t get much after that." The Bills showcased their defensive strength, effectively neutralizing Denver’s offensive threats after the initial score.