The running back landscape has transformed significantly due to injuries affecting many players. In the previous year, only five running backs were selected in the first round of fantasy drafts, a stark contrast to previous years. Bijan Robinson, Saquon Barkley, and Jahmyr Gibbs stood out among these picks, while several others emerged as breakout stars throughout the 2024-25 season.

De'Von Achane of the Miami Dolphins transitioned from a backup role to a top-tier fantasy option, finishing as RB5 with significant contributions in both rushing and receiving. Chase Brown from the Cincinnati Bengals capitalized on injuries in his backfield to secure an RB10 finish, making him a compelling target for next season. Meanwhile, Bucky Irving of the Tampa Bay Buccaneers demonstrated explosive potential, claiming the RB6 position as he edged out his competition. Other notable performances came from Chuba Hubbard, who exceeded expectations in Carolina, and Rico Dowdle of the Dallas Cowboys, who proved to be a valuable asset despite uncertainties about his future.