The Indianapolis Colts and Houston Texans are set to kick off their seasons on Sunday at Lucas Oil Stadium. The Colts have ruled out wide receiver Josh Downs due to an ankle injury and listed kicker Matt Gay as questionable, who will also be inactive. In contrast, the Texans will be without safety M.J. Stewart, who is out with a knee injury.

Despite Stewart's absence, the Texans are generally in solid health, with key players Will Anderson Jr. and Laremy Tunsil returning just in time for the regular season.