As the Indianapolis Colts prepare for the 2025 NFL Draft, bolstering their defensive end position is a top priority. With the recent departure of Dayo Odeyingbo to the Chicago Bears, the Colts must find solid replacements for his 700 defensive snaps from last season. ESPN's Ben Solak suggests targeting Day 2 prospects like James Pearce Jr. from Tennessee and Landon Jackson from Arkansas, both of whom present promising potential. Pearce could be a valuable addition if he slips out of the first round, while Jackson boasts impressive testing results, making him an intriguing developmental option.

The Colts are set on a strong foundation with current players like Kwity Paye and Tyquan Lewis, but with the looming free agency of these key players in 2026, the urgency to add depth is critical. Improving pressure rates, currently ranked 22nd in the league, will also be essential under the new aggressive scheme from coordinator Lou Anarumo.