George Karlaftis was among the key players rested by the Chiefs in Week 18, as the team prioritized maintaining their performance and securing a first-round bye. His absence, along with other stars, sparked criticism regarding the team's intentions, particularly in relation to the Bengals' playoff hopes.

George Karlaftis was selected as an EDGE player for the Week 16 Team of the Week, showcasing his strong performance and impact on the defensive front for the Chiefs.

Karlaftis has been a key player in the Chiefs' defensive line, contributing significantly to the team's pass rush strategy. With Uche's limited role, Karlaftis continues to be a central figure alongside Mike Danna and Charles Omenihu, showcasing the coaching staff's preference for established players in critical situations.

George Karlaftis had a standout performance with two sacks against the Browns, bringing his season total to seven. His impactful plays included stopping Cleveland's opening drive and applying pressure on crucial third downs, contributing significantly to a challenging day for the opposing quarterback.

George Karlaftis played a crucial role in the Chiefs' defense, batting down two passes during a pivotal moment in the fourth quarter, which helped thwart the Raiders' drive and set up a crucial fourth down. His performance contributed to Kansas City's ability to maintain pressure on the Raiders and ultimately secure the victory.