Isiah Pacheco began the season as a strong RB1 option, accumulating 135 rushing yards and one touchdown in the first two weeks. However, a leg injury has kept him sidelined since Week 2. He is expected to be designated to return from injured reserve this week, allowing the Chiefs a 21-day window to evaluate his recovery. Pacheco's absence has led to Kareem Hunt taking on a larger role in the backfield. Upon his return, Pacheco could either reclaim his lead-back position or share touches with Hunt, depending on his readiness. If cleared to play against the Bills, he is projected to be a valuable fantasy asset, given his previous performance and the Chiefs' high-scoring potential. Fantasy managers should monitor updates on his health before making lineup decisions.