The Houston Texans dominated the Los Angeles Chargers, winning 32-12 in the Wild Card round and setting up a challenging matchup against the Kansas City Chiefs at Arrowhead Stadium. Both teams will rely heavily on their running backs, including the Texans' Joe Mixon and the Chiefs' Kareem Hunt and Isiah Pacheco, as they prepare for the Divisional Round. However, fantasy managers are advised against starting Hunt and Pacheco due to their struggles and limited usage in a tough matchup against a formidable Texans defense.

Mixon’s status is uncertain due to an ankle injury, although he is expected to play. Still, his effectiveness against the Chiefs' strong defense is questionable, making him a risky choice in daily fantasy leagues. Analysts suggest looking towards players like James Cook over Mixon for better potential returns.