In the upcoming Super Bowl 59, Patrick Mahomes faces a challenging matchup against Eagles slot cornerback Cooper DeJean, who has demonstrated exceptional performance in coverage. DeJean's impressive 81.5 overall grade marks him as one of the top slot defenders, allowing less than one yard per coverage snap. Meanwhile, Saquon Barkley will have to navigate through the Chiefs' formidable run defense, which ranks 10th in the league, as he contends with linebacker Leo Chenal, known for his reliability against the run.

Key offensive duels also feature Eagles wide receiver A.J. Brown versus Chiefs cornerback Trent McDuffie, and tight end Travis Kelce against linebacker Zack Baun. Each of these matchups highlights potential vulnerabilities in the defenses, particularly for the Eagles, who have made significant improvements in slot coverage since last season.