The NFL's unpredictability continues to challenge fantasy football managers as Week 10 brought unexpected performances from key players. Sam Darnold and Justin Jefferson's struggles against the Jaguars were particularly surprising, while Kyler Murray shined against the Jets.

As the season progresses, teams like the Minnesota Vikings and Arizona Cardinals have shown volatility, with the Vikings struggling in a favorable matchup and the Cardinals bouncing back after a lull. The Kansas City Chiefs remain undefeated, yet their fantasy relevance is questionable.

Coaches and managers must adapt their strategies as some teams, like the Indianapolis Colts, have not lived up to preseason expectations. Meanwhile, the Tennessee Titans and New Orleans Saints have also faced challenges, with players like Will Levis and Derek Carr needing to step up in upcoming weeks.