The San Francisco 49ers suffered a significant setback as they lost the game against the Los Angeles Rams and also two-time Pro Bowl defensive tackle Javon Hargrave to a season-ending injury.

Head coach Kyle Shanahan confirmed Hargrave partially tore his triceps, a blow to the team's defensive line. Quarterback Brock Purdy is day-to-day due to back soreness, while Christian McCaffrey is seeking treatment for his Achilles tendonitis.

The injuries extend to other key players, complicating the 49ers' upcoming match against the New England Patriots as they navigate a challenging season start.