Brock Purdy, quarterback for the San Francisco 49ers, was unexpectedly inactive for Week 12 due to a shoulder issue, despite initial claims of mere soreness from head coach Kyle Shanahan. The team's injury reporting has raised concerns among fantasy managers.

Although Purdy is expected to play in the upcoming game against the Buffalo Bills, his performance may be affected by his injury and the absence of key offensive linemen. The 49ers' playoff hopes are dwindling, making this a crucial matchup.