San Francisco 49ers running back Christian McCaffrey will miss the remainder of the regular season due to a right knee injury, specifically a posterior cruciate ligament issue. Coach Kyle Shanahan confirmed that McCaffrey will be placed on injured reserve for the second time this season, following a previous absence due to Achilles tendinitis.

McCaffrey's backup, Jordan Mason, is also heading to injured reserve with a high ankle sprain. This season has been challenging for McCaffrey, who, despite winning the 2023 AP Offensive Player of the Year, has struggled with injuries and performance issues.