Aaron Rodgers faced a challenging game as the New York Jets suffered a 40-14 defeat to the Buffalo Bills, marking one of the most disappointing losses in his two-decade career. This defeat dropped the Jets to a disappointing 4-12 record, highlighting a season filled with struggles. Rodgers, who aimed to become the fifth quarterback in NFL history to throw 500 touchdown passes, instead found himself making unwanted headlines as he was sacked four times, setting a new career total of 568 sacks, surpassing Tom Brady's previous record of 565.

During the game, Rodgers also threw two interceptions and was penalized for unnecessary roughness while attempting to make a tackle. His performance was subpar, completing only 12 of 18 passes for 112 yards, the lowest yardage he has recorded in a game with multiple interceptions. With the Jets trailing significantly, he was replaced by Tyrod Taylor, who managed to score both of New York's points. Despite the rough outing, interim coach Jeff Ulbrich indicated that Rodgers would likely start in the season finale against the Miami Dolphins.

Rodgers expressed uncertainty about his future, hinting that he might contemplate retirement after this season. The Jets' offensive line struggled, exacerbating the pressure on Rodgers, with injuries affecting key players. The game was marred by penalties, with the Jets committing 16 infractions for 120 yards, which Ulbrich described as frustrating and embarrassing. Despite the loss, wide receiver Garrett Wilson managed to reach a personal milestone by surpassing 1,000 receiving yards for the third consecutive season, providing a rare highlight in an otherwise dismal game.