Week 2 of 2025 delivered a wave of fantasy busts across QB, RB, WR and TE, forcing managers to rethink lineups and smartly pivot for Week 3. Michael Penix Jr. and J.J. McCarthy faltered in prime time, while a host of running backs—Henry, Hall, Charbonnet, Pacheco, Hunt and more—never found their footing. WRs like A.J. Brown, Marvin Harrison Jr. and Drake London cooled after strong openings, and tight ends such as Mark Andrews and T.J. Hockenson offered limited fantasy returns. Bounce-back potential remains for several, but risk has clearly risen across the board.

Rosters should shift toward safer floors and clearer use-cases in Week 3, with attention to upcoming matchups against softer defenses and potential in-game script shifts. The busts spotlight several buy-low windows, particularly at WR and TE, where targets and red-zone usage could swing dramatically with a favorable game plan. Fantasy managers should weigh the rest-of-season trajectory against Week 2 volatility and adjust accordingly.

Overall, Week 2 underscored the value of depth and matchup-fueled decisions. Staying ahead requires identifying hidden Week 3 opportunities among RBs with clearer roles, WRs in jam-friendly offenses, and TEs who still command a red-zone presence despite rough Sundays.

Seattle rode a sharper offensive game plan to a 31-17 win in Pittsburgh, moving to 1-1 while nursing two key absences on defense. Sam Darnold delivered efficient quarterback play, Kenneth Walker III powered the ground attack, and Derion Kendrick delivered a momentum-shifting end-zone interception. JSN and Cooper Kupp provided reliable targets with 103 and 90 receiving yards, respectively, while Zach Charbonnet ceded ground and Abe Lucas dealt with elite rushers.

Overall, Seattle showed a balanced attack capable of sustaining fantasy value through both the air and the run, with a defense that bottled up the Steelers and a few youngsters rounding into form. If the line can hold up and the WRs stay productive, this offense has viable weekly upside, even amid injuries.

SportsLine's Week 2 longshots center on sudden role changes and red-zone chances. Zach Charbonnet is priced at +220 to score for Seattle after a 58% snap share in Week 1, with Seattle facing Pittsburgh next. DeMario Douglas sits at +400 to find the end zone for New England, a sleeper in a Dolphins shootout. Trevor Lawrence checks in at +500 for a rushing-style TD against Cincinnati, offering a high-risk, high-reward path.