The New York Giants are set to face the Seattle Seahawks in Week 5 of the NFL season, with the Giants struggling in past cross-country games. Their record of 0-5 against the spread west of the Mississippi last year raises concerns, especially as they come off a mini-bye week.

Meanwhile, the Miami Dolphins will also be dealing with short rest as they head to New England, where they have yet to cover a spread this season. SportsLine analyst Larry Hartstein has identified key betting strategies for these matchups, including his top picks for the week.