The San Francisco 49ers are facing a significant setback as defensive tackle Javon Hargrave is likely out for the season due to a partially torn triceps sustained in a recent game against the Los Angeles Rams.

Head coach Kyle Shanahan expressed the impact of Hargrave's injury, highlighting his performance in the match and how it changes the team's dynamics moving forward. Additionally, quarterback Brock Purdy is dealing with back soreness, while linebacker Dee Winters has aggravated an existing ankle injury.