The San Francisco 49ers are making significant roster changes ahead of their matchup against the Detroit Lions, particularly in their offensive line due to a series of injuries. Undrafted rookie center Drake Nugent has been elevated to the active roster and is set to make his NFL debut during the highly anticipated 'Monday Night Football' game at Levi’s Stadium. Nugent, a former standout at Stanford, has been brought in to help bolster the 49ers' offensive line, which has been severely impacted by injuries.

In a move to address their depth, the 49ers placed guard Aaron Banks on injured reserve. Additionally, they activated rookie linebacker Tatum Bethune, who had been sidelined for the past five games due to a sprained knee suffered in Week 11 against the Seattle Seahawks. The team also elevated defensive lineman Alex Barrett from the practice squad. The recent injury list for the 49ers includes notable offensive tackles Trent Williams and Jaylon Moore, both of whom have been placed on injured reserve, alongside Spencer Burford, who has been ruled out for the game.

To further strengthen their offensive line, the 49ers signed several new players, including Austen Pleasants, Charlie Heck, and Matt Hennessy, to the active roster. Nugent’s collegiate career includes 42 games played with 39 starts, where he earned recognition as an All-Big Ten selection and contributed to Michigan's national championship victory in his final season.

In a significant blow to the San Francisco 49ers, left tackle Trent Williams will miss Sunday’s game against the Green Bay Packers due to an ankle injury, forcing Jaylon Moore to step in as the starter. This matchup marks the first start for quarterback Brandon Allen since the 2021 season, as Brock Purdy is sidelined with a shoulder issue.

Additionally, the 49ers will be without key players including Nick Bosa and Charvarius Ward, while the Packers are also dealing with injuries to Jaire Alexander and Edgerrin Cooper.

Brock Purdy will miss his first start as the 49ers' quarterback due to a right shoulder injury, complicating the team's playoff aspirations. Brandon Allen is set to start against the Green Bay Packers, with Joshua Dobbs as the backup.

Defensive end Nick Bosa will also be absent due to hip and oblique injuries, alongside several other key players. The 49ers face a tough challenge as they prepare for this crucial matchup at Lambeau Field.

The San Francisco 49ers are hopeful to have tight end George Kittle back for their upcoming game against the Green Bay Packers, but the status of pass rusher Nick Bosa remains uncertain due to injury. Kittle missed the last game against the Seattle Seahawks, contributing to a disappointing loss that jeopardized the team's playoff chances.

Bosa, who left the Seahawks game with a hip and oblique injury, is making progress but is still uncertain about his availability. His absence has been significant in the 49ers' recent struggles, as they have blown leads in multiple games this season.

Quarterback Brock Purdy is also dealing with a shoulder injury but is expected to play. Meanwhile, running back Christian McCaffrey and left tackle Trent Williams are managing their own injuries as the team prepares for a crucial match.

The San Francisco 49ers faced a challenging defeat against the Seattle Seahawks, particularly after losing star defender Nick Bosa to injury. His absence allowed Seattle to rally for a 20-17 victory, raising concerns about the 49ers' playoff aspirations.

Head Coach Kyle Shanahan indicated uncertainty regarding Bosa's status for upcoming games. The 49ers' struggles extend beyond Bosa, as they have now blown fourth-quarter leads in three divisional matchups this season, leaving them in a precarious position in the NFC West.

Despite the loss, Jauan Jennings stood out offensively for San Francisco, catching 10 passes for 91 yards and a touchdown. However, the team needs to improve its late-game execution to avoid further setbacks.