Drake Nugent, an undrafted rookie center, is set to make his NFL debut for the 49ers against the Lions. He was elevated to the active roster due to a wave of injuries affecting the offensive line. Nugent previously played at Stanford and was an All-Big Ten selection during his final season at Michigan, where he contributed to a national championship win.

Drake Nugent was waived as part of the 49ers' roster moves while finalizing their 53-man roster.