George Kittle topped SF’s Week 1 offense with an elite PFF grade, while Jake Tonges flashed as a reliable second TE and Ricky Pearsall carved out a clean 77.2 WR grade in a banged‑up receiving corps. Jacob Cowing offered a versatile target role as SF leaned on the line with strong run blocking from Ben Bartch and Jake Brendel. SF’s defense dictated the outcome, led by Sam Okuayinonu on the edge and Nick Bosa-powered pass rush, sealing a 17‑13 win at Seattle.

Kendrick Bourne's return to San Francisco after Jauan Jennings' shoulder injury reshapes the 49ers' WR pecking order. Bourne, familiar with Kyle Shanahan's system, could contribute immediately if Jennings misses time, especially with Brandon Aiyuk out (PUP) and Cowing and Watkins banged up. In the short term, Pearsall, Valdes-Scantling, and Gage figure to pick up the rest of the workload, while Bourne stabilizes the group with veteran steadiness and route-running savvy.

Jennings' injury creates a window for Bourne and the supporting cast to prove value in a run-first, pass-efficient offense. Bourne's season-ready presence could elevate SF's floor in fantasy, but the exact roles will hinge on Aiyuk's status and Jennings' recovery, making Week 1 a vivid test of SF's depth at wide receiver.

Jauan Jennings cleared in final MRI and expected to play Week 1 against Seattle, though SF will ease him into practice. With Brandon Aiyuk on the PUP and Jacob Cowing IR, Jennings would anchor SF’s top two receivers alongside George Kittle and Christian McCaffrey, lifting the passing game floor if he’s healthy enough to contribute. If Jennings is limited, depth options like Ricky Pearsall, Jordan Watkins, and Jacob Cowing could absorb added targets in a potential high-volume opener.

Jennings’ career-best 77 receptions, 975 yards, and six TDs set a high bar for Week 1 expectations. Seattle’s Week 1 test will hinge on practice progression and game flow, shaping target distribution and the fantasy upside of SF pass-catchers. Managers should map Jennings’ role to practice status and Seattle’s coverage to set accurate lineups.

San Francisco claimed Jordan Jefferson off waivers, boosting interior defensive-line depth as they navigate a crowded rotation. Jefferson, LSU product and 2024 fourth-rounder, has upside but limited NFL production to date, with roughly 150 defensive snaps as a rookie in Jacksonville. In SF, he immediately slots into a six-man interior DL group alongside Jordan Elliott, Alfred Collins, Kalia Davis, Evan Anderson, and the incumbent depth, signaling flexible alignment from first to fifth in the rotation.

This roster churn comes alongside Marquez Valdes-Scantling’s addition and Jacob Cowing’s IR designation, underscoring the 49ers’ willingness to tinker at the deadline. Jefferson’s youth and pedigree give him a path to meaningful snaps if he latches onto a niche in pass rush or run defense. The question remains which three players SF will cut or move to IR to fully accommodate the new depth, and how soon Jefferson can translate potential into production.