Jake Brendel was the victim of a low hit by Dolphins safety Jevon Holland during a play in which Kyle Juszczyk caught a 20-yard pass from Brock Purdy. This incident highlights the physical nature of the game and the risks players face on the field, particularly for those in the trenches like Brendel.

Jake Brendel, along with his offensive line teammates, expressed gratitude for Brock Purdy's extravagant holiday gift of new cars, showcasing the strong bond and appreciation within the team after a season of hard work protecting the quarterback.

Jake Brendel, the center for the 49ers, made a friendly wager with former Iowa tight end George Kittle regarding the outcome of the UCLA-Iowa game. Brendel, a UCLA alum, celebrated the Bruins' victory, which added to Kittle's string of losses in Iowa-related bets this season.

Jake Brendel earned a 70.0 overall grade, with a 49.1 pass-blocking grade, and did not allow any pressures on his pass-blocking snaps. His performance contributed to the offensive line's overall effectiveness in protecting Purdy during the game.

Center Jake Brendel expressed his disappointment over Aiyuk's injury, emphasizing the impact of losing a key offensive weapon. He highlighted the need for the rest of the roster to step up and maintain productivity despite the setbacks caused by injuries to multiple players.