The Kansas City Chiefs maintained their perfect record by defeating the San Francisco 49ers 28-18, marking their sixth consecutive win of the season. The 49ers, plagued by injuries, struggled to keep pace with the Chiefs' aggressive defense and offensive plays.

Brock Purdy faced significant pressure, throwing three interceptions while Patrick Mahomes contributed with a rushing touchdown. Despite some bright moments from the 49ers, including a touchdown run by Purdy, they couldn't overcome the Chiefs' lead.

The Kansas City Chiefs continued their impressive start to the season with a 28-18 victory over the San Francisco 49ers, marking Patrick Mahomes' first 6-0 start as a starter.

Brock Purdy struggled against the Chiefs' defense, throwing three interceptions while managing to score two rushing touchdowns. The 49ers faced significant injury woes, losing Brandon Aiyuk to a potential ACL injury, adding to their list of unavailable players.

Despite the 49ers' efforts, including a solid performance from tight end George Kittle, the Chiefs' defense and Mahomes' dual-threat ability ultimately secured the win.

The San Francisco 49ers and Seattle Seahawks are battling injuries ahead of their Thursday Night Football game. The 49ers have officially placed safety Talanoa Hufanga on injured reserve due to ligament damage, sidelining him for four games. Kicker Jake Moody is also out with a high ankle sprain.

Other key players missing include defensive lineman Jordan Elliott and linebacker Demetrius Flannigan-Fowles. However, tight end George Kittle and linebacker Fred Warner are cleared to play. The Seahawks will also be without several starters, including Byron Murphy II and Riq Woolen.

In response to Hufanga's absence, rookie Malik Mustafa will step in at safety. Newly signed kicker Matthew Wright will handle kicking duties for the 49ers, who may also call up defensive linemen from the practice squad.