The San Francisco 49ers are facing significant challenges on defense following the likely season-ending injury to star defensive tackle Javon Hargrave. While previously one of the NFL's top units, the team has struggled with quarterback pressure and run defense, allowing an average of 6.11 yards per play.

Head coach Kyle Shanahan emphasizes the need for adjustments, particularly with Hargrave's absence affecting their ability to generate pressure. As they seek to rebound from recent losses, the team plans to rely on new faces and adapt their defensive strategy.