The San Francisco 49ers face challenges ahead of their game against the Los Angeles Rams, potentially missing key players including George Kittle, Christian McCaffrey, and Deebo Samuel due to injuries. Tight end Kittle is listed as doubtful with a hamstring issue, while McCaffrey and Samuel are already ruled out. On defense, Nick Bosa and Charvarius Ward are questionable but could impact the game significantly.

In positive news, safety Talanoa Hufanga is set to return after recovering from a torn ACL, bringing relief to the defense. Despite the injuries, quarterback Brock Purdy is confident in the team’s depth, emphasizing the need for adaptability and effective playcalling.