The San Francisco 49ers face a challenging matchup against the Los Angeles Rams without key offensive players. All-Pro tight end George Kittle is doubtful due to a sore hamstring, while All-Pro running back Christian McCaffrey remains on injured reserve with Achilles tendinitis, and star receiver Deebo Samuel is out with a calf strain.

If Kittle misses the game, backup tight end Eric Saubert is expected to step in. Quarterback Brock Purdy has limited experience playing without these stars, indicating potential struggles ahead.

Additionally, while the team receives safety Talanoa Hufanga back from injury, notable defensive players like Nick Bosa and Charvarius Ward are listed as questionable, adding further uncertainty to the game.