The Los Angeles Rams are set to face their NFC rivals, the San Francisco 49ers, at a critical moment when the 49ers are missing star players Christian McCaffrey and Deebo Samuel. Rams head coach Sean McVay noted the impact of these absences but recognized the 49ers' depth. This matchup comes after the 49ers suffered a disappointing loss to the Minnesota Vikings, providing the Rams an opportunity to capitalize.

Despite injuries to key players, including two of Matthew Stafford's starting wide receivers, the Rams are working on improving their offensive cohesion. Stafford faces challenges with his new-look lineup, aiming for a bounce-back performance following a tough game against the Arizona Cardinals.