The San Francisco 49ers are facing a challenging matchup against the Buffalo Bills in Week 13, with quarterback Brock Purdy listed as questionable due to a shoulder injury. While he participated fully in practice, his status remains uncertain. The team will be without key players, including left tackle Trent Williams and defensive end Joey Bosa, both ruled out due to injuries.

Purdy's potential return could provide a much-needed boost to the 49ers' offense, which has struggled with injuries. However, the expected snowy conditions in Orchard Park may hinder their passing game. Additionally, the absence of Williams, a top offensive tackle, and Bosa, the team's leading sack artist, raises concerns for San Francisco's performance against the Bills.