Christian McCaffrey is set to make his season debut for the San Francisco 49ers after being activated off injured reserve. His return comes after recovering from Achilles tendinitis and calf tightness, which sidelined him since Week 1.

Head coach Kyle Shanahan praised McCaffrey's recent practice performance, indicating he is ready to contribute against the Tampa Bay Buccaneers. The 49ers, currently at 4-4, have struggled in his absence, relying on Jordan Mason for rushing duties.