The Kansas City Chiefs maintained their perfect record by defeating the San Francisco 49ers 28-18, marking their sixth consecutive win of the season. The 49ers, plagued by injuries, struggled to keep pace with the Chiefs' aggressive defense and offensive plays.

Brock Purdy faced significant pressure, throwing three interceptions while Patrick Mahomes contributed with a rushing touchdown. Despite some bright moments from the 49ers, including a touchdown run by Purdy, they couldn't overcome the Chiefs' lead.