San Francisco 49ers rookie running back Isaac Guerendo is likely to miss the upcoming game against the Miami Dolphins due to a hamstring injury. This injury follows a series of setbacks for the team's running backs, including Christian McCaffrey and Jordan Mason, who are out for the season.

Head coach Kyle Shanahan did not disclose the injury during a previous conference call, but sources indicate Guerendo's status is dire. Patrick Taylor Jr. is expected to step in as the primary running back, with Israel Abanikanda and Ke'Shawn Vaughn as potential options.