George Kittle, the standout tight end for the San Francisco 49ers, will miss the game against the Seattle Seahawks due to a hamstring injury sustained in the previous week's victory over the Tampa Bay Buccaneers.

Despite being hopeful for Kittle's availability, coach Kyle Shanahan confirmed his absence after Kittle was limited in practice leading up to the game. His absence is significant as he leads the team in receptions and touchdowns, particularly in crucial red zone situations.