The San Francisco 49ers faced a challenging game against the Kansas City Chiefs, suffering a 28-18 defeat that highlighted their injury woes. Star receiver Brandon Aiyuk is out for the season with a torn ACL and MCL, while Deebo Samuel and Jauan Jennings also missed the game, leaving Brock Purdy with limited options.

Despite the setbacks, coach Kyle Shanahan remains optimistic about the team's depth and potential for improvement. The 49ers will explore trade options to bolster their roster ahead of the deadline.