Isaac Guerendo, the San Francisco 49ers' running back, is facing a hamstring injury that may prevent him from playing against the Miami Dolphins. This season has been challenging for the 49ers' backfield, with key players like Christian McCaffrey, Jordan Mason, and Elijah Mitchell suffering season-ending injuries.

With Guerendo's 381 rushing yards and four touchdowns, he has stepped up as a leading option. Additionally, left tackle Trent Williams is also likely to miss the game due to an ankle injury, raising concerns for the team's offensive line.

The 49ers currently hold a 6-8 record and remain in contention for a playoff spot, but they must win their remaining games and rely on outside help to secure a postseason berth.