San Francisco 49ers rookie running back Isaac Guerendo is likely to miss the upcoming game against the Miami Dolphins due to a hamstring injury. This injury follows a series of setbacks for the team's running backs, including Christian McCaffrey and Jordan Mason, who are out for the season.

Head coach Kyle Shanahan did not disclose the injury during a previous conference call, but sources indicate Guerendo's status is dire. Patrick Taylor Jr. is expected to step in as the primary running back, with Israel Abanikanda and Ke'Shawn Vaughn as potential options.

The San Francisco 49ers and Los Angeles Rams faced off in a challenging game marked by poor offensive performance, with the first 19 drives resulting in either punts or field goals.

Puka Nacua stood out as the only offensive player meeting fantasy projections, while Kyren Williams and Isaac Guerendo struggled despite heavy usage.

Guerendo played through a foot injury, and despite a lackluster performance, he remains a potential fantasy starter for the upcoming week against the Miami Dolphins.

Demarcus Robinson also played through injuries, maintaining his role as the Rams' third receiver, while Tutu Atwell has stepped up in recent weeks.

The San Francisco 49ers have activated linebacker Dre Greenlaw for their game against the Los Angeles Rams, marking his return after a significant injury during last season's Super Bowl. Greenlaw, who had been on the physically unable to perform list, is expected to bring back his impactful presence to the defense.

In a roster move, the 49ers placed offensive lineman Ben Bartch on injured reserve due to an ankle injury. Greenlaw, a key player for San Francisco, recorded impressive stats before his injury and is anticipated to enhance the team's defensive capabilities.

The San Francisco 49ers welcomed back linebacker Dre Greenlaw and defensive end Nick Bosa for their matchup against the Los Angeles Rams. Greenlaw, returning from a torn Achilles, had been activated from the physically unable to perform list, while Bosa made his comeback after missing three games due to hip and oblique injuries.

Greenlaw's return is significant as he was a key defensive player before his injury in last season's Super Bowl. The 49ers have missed his presence on the field, particularly against the run.

The NFC West is highly competitive as the season nears its end, with all four teams still in contention for the division title. The upcoming matchup between the Los Angeles Rams and San Francisco 49ers is crucial, as the loser risks elimination from playoff contention.

The Rams, currently at 7-6, have improved significantly since their bye week, while the 49ers, at 6-7, face a dire situation due to injuries, particularly in their running back corps. With key players potentially sidelined, this game will test San Francisco's depth against a Rams team that has found its rhythm with its star players.

Despite the injuries, the 49ers have historically performed well against the Rams, making this matchup unpredictable. The prediction leans towards a close game, highlighting the importance of this divisional clash.