The San Francisco 49ers welcomed back linebacker Dre Greenlaw and defensive end Nick Bosa for their game against the Los Angeles Rams. Greenlaw, returning from a torn Achilles tendon suffered in last season's Super Bowl, was activated from the physically unable to perform list. Bosa, who missed three games due to hip and oblique injuries, was also active.

Greenlaw's absence has been felt, particularly in run defense, as he was a key player for the team in the previous seasons. The 49ers made roster adjustments, placing offensive lineman Ben Bartch on injured reserve.